Profile Management and App-V

Last published : Oct 12, 2026
You can use Profile Management in the same environment as Microsoft Application Virtualization 5.x (App-V 5.x).
Note:
Profile Management supports only globally published App-V.
Exclude the following items using Profile Management exclusions:
  • Profile Management\\File system\\Exclusion list\\directories:
    • AppData\Local\Microsoft\AppV
    • AppData\Roaming\Microsoft\AppV\Client\Catalog
  • Profile Management\\registry\\Exclusion list:
    • Software\Microsoft\AppV\Client\Integration
    • Software\Microsoft\AppV\Client\Publishing
For instructions on setting exclusions, see Include and exclude items.
If the UserLogonRefresh setting is enabled in App-V, disable the Profile streaming policy in Profile Management. This restriction is the result of an incompatibility of UserLogonRefresh with Profile streaming.
For an example of how to sequence an App-V application, see <https://docs.microsoft.com/en-us/windows/application-management/app-v/appv-sequence-a-new-application>.
For information on configuring third-party Profile Management solutions with App-V enabled, see <https://docs.microsoft.com/en-us/microsoft-desktop-optimization-pack/appv-v5/performance-guidance-for-application-virtualization-50>. Do not include Software\Classes on Microsoft Windows 10 systems.